JO Renew Vaginal Moisturizer Original formula 4 fluid ounces is a rich moisturizing cream designed to provide comfort for women experiencing vaginal dryness. The fusion of water and silicone provides a luxurious texture and a lasting application. Designed to gently moisturize vaginal area for daily and intimate comfort. Vaginal dryness naturally affects women as they age. However, other factors that may cause vaginal dryness include: diabetes, chemotherapy, use of antibiotics, birth control pills, antidepressants, stress and lack of sleep. A fusion of water and silicone base.